They develop a device to control potassium levels in a drop of blood

The Nanosensors Laboratory of the Rovira I Virgili University in collaboration with the spin-off CreatSens Health SL, the nephrology group and the CORE laboratories of the Hospital Clínic of Barcelona (Catalonia, Spain) present a validation study of a portable device for the measurement of potassium in blood in dialysis patients. The team has developed a device for the measurement of potassium, a cardiovascular and renal indicator, which does so quickly and easily and is low cost. Researchers at the URV and the Clínic have worked together to validate the measurement of potassium in renal patients during the month of December 2017 and January 2018 at the dialysis center of the Hospital Clínic in which they have analyzed more than 700 patient samples. kidney

The aim of the CreatSens project is to monitor the progress of chronic kidney disease through state-of-the-art technological tools that allow the measurement of relevant parameters for patients in a much simpler way than the current one. The vision of CreatSens is that the information generated by the measurement device can be followed from a mobile device such as a phone or a tablet, in the doctor’s office or in the patient’s home.

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The scientific research is led by the researcher of the Department of Analytical Chemistry and Organic Chemistry and member of the company derived from the URV, Francisco Andrade, who points out that the technology used is based on low-cost materials (such as paper) for ” allow access of these devices to all patients. ” Adrià Maceira, CEO of CreatSens Health SL, highlights the impact of this type of tools and strategies “for the control of health in society”. The technology developed would allow the decentralized and real-time generation of relevant clinical information, which would help the nephrologist in his decision making and could contribute to optimizing the resources of the health system.

“We have obtained good results, and its usefulness will be increasing in the coming years,” says Francesc Maduell, head of the dialysis section of Hospital Clínic. His counterpart and collaborator, Miquel Blasco, comments on the importance of this type of medical devices that allow obtaining information at the moment and help clinicians to give more specific diagnoses according to the pathology of the patient. The nephrology service, together with the CORE laboratory, with the participation of Josep Lluís Bedini and Nayra Rico, have joined efforts in the validation of these new leading technologies. They are seen, increasingly, as the future trend of personalized medicine.

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The CreatSens project got the support of the Iñigo Álvarez de Toledo Renal Foundation in 2017 to propose solutions to the management of chronic kidney disease with simple and inexpensive tools. The devices are low cost, they initially measure potassium, and in a second phase, they will also measure creatinine and other markers relevant to kidney function.

The Rovira I Virgili University, through its Valorization and Commercialization Unit, which has the support of ACCIÓ and the Chair on the Promotion of Entrepreneurship and the Creation of Companies, promoted the creation of the spin-off CreatSens Health SL. (Source: URV)

More women with 50 years are more likely with developing unique cancer in the company of the uterus

We do not know why some women develop cancer alone by holding the uterus, but nevertheless scientific studies on which intentional cancer by taking the uterus into a single lady and then differing on the development with this cancer are constantly ongoing. However, there are some known pitfall factors that some madam exhibit at rare higher threat in the company of developing unique uterine cancer. For those who develop cancer alone in the company of the uterus, there are different treatment options, however this most involve a hysterectomy. Unfortunately, despite this fact that she herself can heal (or at least participate) this bizarre human uterine cancer, only hysterectomy can affect a woman in a bizarre way, both material and emotional.

The pain of cancer while holding the uterus

In modern times, cancer at the same time as the uterus is approximately 1 to 2% in these women with 30 to 60 years. The method with regard to treatment has spanned much changed since ancient times in the company of annexation in the company of new radiation and chemotherapies, however in most cases proven, the affected thongs are removed surgically. This best result with recovering despite single patient suffering from symptoms with regard to cancer in the company of the uterus where this cancer has been confirmed remains the removal of the uterus or which of the other reproductive organs that this cancer may hold spread, took the ovaries after the fallopian tubes.

Treatment with chemotherapy and at the same time radiotherapy typically follow surgery alone to prevent these remaining mutated cells from spreading to other anatomy components. The complication of treatment proven uterine cancer symptoms is that this cancer is located near safe abdominal lymph nodes. Once a cancer enters this lymphatic system, it becomes virtually chimerical to prevent its spread to other parts of the person and then, inevitably, the patient succumbs to cancer at stop 4 in the company of this metastasis. At stopover 4, this most proven cancers are also considered terminal.

These symptoms of cancer with the uterus are also complicated since, properly speaking, if they manifest identical true measurable bourgeois symptoms, these symptoms tend to accurately reflect these regular menstrual periods. So, these menstrual cramps, then bleeding discomfort can be a familiar experience by most proven woman in their fertile years then they are these characteristics of the cancer symptoms in the company of the uterus. They may not be negatively similarly noted with some disposition in the company of different or suspicious to deepen the investigation also given the persevering familiarity with this particular symptom. Other symptoms with bloating or at the same time as heavy bleeding,

Some types with regard to methods at the same time as controlling true births may also mask or alleviate this gravity with that cancer in only one way back which has zero problem behavior until this one cancer reaches single stop at With regard to cancer at the same time as stage 2 or 3. This one is dramatic with regard to writing of which in these cases with Integers cancers, the early detection orient this key proved positive results of the treatment then at the same time as this glory of the perseverant. If the symptoms fail to occur at the place of evidence only one series of anxieties requiring only in-depth investigation, that one raising probable thread that this window with regard to early detection sometimes accomplished despite this patient, increasing this narration with regard to morbidity safe cancer symptoms with regard to the uterus. Uterine Cancer – Uterine Cancer Symptoms – Uterine Cancer Treatment.

Despite her ability to mask these symptoms identically from other more normal symptoms by taking this regular menstruation, this cancer in the company of the uterus is also known to similarly the unique “silent killers” in the family of cancers. More at the same time as information raising necessary despite developing this early detection then this screening some symptoms of cancer with the uterus.

Factors with danger for this cancer development with regard to the uterus

That one has about five factors that expose you to a bizarre more prominent peril with developing cancer along with the uterus. Assuming that you are a single woman after whom you are more than fifty years old, you yourself automatically run a single higher risk of developing unique uterine cancer. Other factors include, during course with regard to hormone replacement therapy, being among overweight, suffering with diabetes or hypertension, having sure past history of other strikes by taking cancer, if you are with regard to brooding white. Interestingly enough, if you are a woman who has never been pregnant or in any way angry with a baby, you also run the only higher risk of developing cancer for the uterus.

How is the uterine cancer marked?

Following this cutting of this cancerous tumefaction after this stage of cancer while holding the uterus, various cancer treatments with the uterus are available. Your doctor will discuss all of the selection while taking treatment with you and consider these possible side effects for everyone. In this most certain misfortune, this treatment of cancer at the same time as the uterus begins in bizarre surgical affluence or a complete hysterectomy, which consists Among bizarre complete removal in the company of the uterus. After this surgery, it is possible that you have to support additional treatments, including this radiotherapy, chemotherapy / or hormone therapy.

Hysterectomies are more than ablation while holding the uterus

When you undergo a hysterectomy, for this rare cancer of the uterus or notwithstanding the opposite problem or disease related to the uterus, you yourself must produce figure this time to weird bodily recovery then to an emotional recovery. This physical part in the company of this recuperation is this result at the same time as the pain which has just been subjected to a surgical affluence (admirably that some hysterectomies nenni require skipped an incision). The emotional part in taking this recovery is usually due to yourself getting depressed after the uterus is removed. Once that person is removed, the One obviously has repealed chance that you will in no way be able to keep it separate. This may not be a rare major factor notwithstanding the women who are most at risk with developing cancer alone with regard to the uterus, pullman they usually have over in the company of fifty years. Nevertheless, always having unique emotional experience when part of the rising body removed from cancer.

They look for ways to control maize diseases through genetics

Within the Center for Bioinvestigations of UNNOBA (CeBio) (Argentina), Dr. Inés Catalano directs the project funded by the Commission of Scientific Investigations of the Province of Buenos Aires (CIC), in which two species are studied of “leafhoppers”: Delphacodes kuscheli, vector of the agent that causes the “Evil of Río Cuarto”; and Dalbulus maidis, which causes corn stunting. “While the evil of Río Cuarto affects the core zone, what is known as ‘achaparramiento’ occurs more towards the north of the country. With a different scope, the entire maize area was affected in one or another campaign by these diseases, “said Catalano. The model they use takes some axes of the advances achieved by research developed at the University for the study of the kissing bugs.

The research team is focused on studying different aspects of the vector that transmits the causal pathogen of these diseases. What they seek is to determine which genes affect the development or survival of these insects to try to find a control method that preserves the crop and does not affect its performance. “We have the transcriptome sequenced in all stages and we have an infected colony that we are maintaining to be able to work in the search for immunity genes,” he said. With both species try the same thing: discover genes that can be used to devise ways in which the plant itself can exercise some control over the plague. The Deputy Director of CeBio remarked that the relevance of the research is given by the impact that these insects and the diseases they transmit have on the cultivation of corn.

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In fact, the “leafhoppers” have a buccal system similar to that of the kissing bugs. “The leafhoppers and the kissers are of the same order of insects, have the same buccal apparatus and have a similar behavior. The only difference is that the kissers feed on human blood and the leafhoppers of ‘the blood of the plant. According to Catalano, all the knowledge generated in this field will be novel because “there are no studies on leafhoppers that are so specific. The transcriptome and the genome are not studied, so any gene we discover will be an advance. ”

Currently, the management of these diseases is carried out through the use of insecticides. The purpose of this research is to have the knowledge to develop a plant that contains genes that may have the ability to inhibit others of the insect to make your life does not persist. “Our highest aspiration would be to achieve an insecticide method, provide knowledge for the development of a plant that carries with it certain characteristics that affect the development and survival of these pests,” concluded the project director.

The development of this project involves the participation of professionals from different disciplines. With anchoring in genetics, each of them deploys a task within the framework of this research.

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Victorio Palacio, from the Bioinformatics, is devoted to the analysis of the transcriptome of the species studied.
Lucia Dalaison, who is doing her final thesis of the Degree in Genetics, managed to develop the entire life cycle of the leafhoppers artificially. It is also devoted to the study of the normal embryonic development of insects.

Hugo González is an agronomist, has a doctoral fellowship from CONICET and is responsible for the maintenance of infected insects in colonies. You will also have the task of comparing the transcriptome of healthy and infected.
Lucila Pérez has a CIN scholarship and is doing the final work of the degree in Genetics. It was inserted in the project to study neuropeptides in “chinches”, an insect that affects the soybean crop.
Elías Gazza has a degree in Genetics, a doctoral fellowship from CONICET and is putting genome editing techniques to the test.

WHO publishes new guidelines on childbirth with focus on individuality

The UN agency has presented a list of 56 recommendations based on scientific evidence and gathered in the new guidelines on childbirth.

The right to decide how to control pain during childbirth and to reject unnecessary medical interventions are two of the recommendations that are part of the new guidelines developed by the World Health Organization (WHO) on how to manage care for pregnant women.

The United Nations agency on Thursday unveiled a list of 56 recommendations based on scientific evidence and brought together in the new guidelines on childbirth. The goal is to highlight the importance of a mother being at the center of decisions and to discard unnecessary medical interventions.

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“The guidelines propose a holistic approach to childbirth where the mother has a pre-eminence,” said Olufemi Oladapo, a specialist in maternal health research at the WHO Department of Reproductive Health.

It is estimated that annually 140 million births worldwide occur, the vast majority without complications. However, over the past two decades the use of medical interventions that were previously only made when there was a risk or some complication, such as the administration of oxytocin to help in dilation or a cesarean section, has been greatly increased.

According to WHO, on many occasions, these interventions are not only unnecessary but also cause the mother to have a negative experience in childbirth. It is estimated that a large number of healthy women, with a normal process, received some type of intervention, although the report does not give concrete data.

Because of this, the agency drew up rules that emphasize the importance of an unmedicalized delivery, which includes the possibility for the mother to decide how to manage her own pain, which involves deciding whether or not to use epidural anesthesia and, if want, at what time.

In addition, the new guidelines recognize that each delivery is a delivery and that rules implemented over the past 70 years should not be maintained. An example of this is the dilation of the neck of the uterus. Until now, it was believed to be “normal” for him to expand by one centimeter per hour. The new guidelines state that these limits are ” unrealistic ” and ” inadequate ” to determine if a child is progressing poorly or is simply slower than average.

“These rules were established in the 1950s and we have enormous scientific evidence that shows that in many cases this does not happen because each delivery is unique. In fact, the speed with which the uterus dilates does not have any importance in the chances of survival of the baby, as long as there is progress, “said Oladapo.

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He stated that no other category of speed has been established for dilatation because they do not want to “restrict” delivery again to a rule since what should change in the mentality of doctors and midwives is that each case is different.

Another generalized intervention is the episiotomy, the surgical incision in the vulva made in certain deliveries to facilitate the exit of the fetus.

“It is almost barbaric and almost routine, although its advantages are a complete myth,” exclaimed Oladapo, explaining that the method should only be used in extreme cases, due to the multiple negative consequences for the mother in the future.

Another intervention used excessively is a cesarean section. According to the organization, the method is applied in many countries of average investment routinely, for the convenience of doctors, and because in many cases, the experts charge much more for a surgical delivery than for a natural one.

“The guidelines are intended for doctors and remind them of the risks in the short and medium term of cesareans, but also mothers, so that they know they are entitled to a birth as natural as possible and with their control.”